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KMID : 0358419640070020001
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Korean Journal of Obstetrics and Gynecology
1964 Volume.7 No. 2 p.1 ~ p.4
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Oxygen uptake of Human Placental Tissue as Affected by Selected Drugs
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鄭載勳/Chung, Jae Hun
金東星/金圭珍/權秉日/Kim, Dong Sung/Kim Kyu Jin/Kwon, Byung Il
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Abstract
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Very few human tissuse other than the placental tissue are readily available for in vitro studies,.
Despite this fact, little is known about the influence of metabolites or pharmacological agents upon this tissue. Any knowledge that may be obtained about the behavior of this complex organ, further-more,may assist in understanding some unsolved problems of human reproduction.
Experimental drugs used are pitocin, Methotrexat, Endoxan (Cyclophosphamide) and Nitromin. The tissuse were obtained in various gestational ages and normal term placenta.
The rate of oxygen consumption of fresh human placental tissue was measured by Warburgs standard manometric technique.
The result obtained are summarized as follows
1) Progressive decline in oxygen uptake with advancing pregancy from QO 2.80,u 102/mg dry weight /hour at 6 weeks gestation, 2. 44 at 14 weeks, 2.15 at 16 weeks. 2.01 at 20 weeks, 1.20 at 28 weeks and 1.21 at term.
2) The Q02 of human placenta in various gestation is stimulated by pitocin.
3) The Q02 of human placental tissue is depressed by Methotrexate.
4) The Q02 of human placental tissue is depressed by Endoxan (Cyclophosphamide) and Nitromin.
These drugs exerted depression of oxygen uptake at term placenta significantly.
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